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KMID : 0861020170320050007
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Korea Journal of Herbology
2017 Volume.32 No. 5 p.7 ~ p.12
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Anti-skin-aging Effect of Mori Folium through decreased Advanced glycation end product (AGEs)
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Lee Ah-Reum
Kim Soo-Hyun
Kim Su-Ji
Kim Kyeong-Jo
Kwon Oh-Jun
Choi Joon-Young
Roh Seong-Soo
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Abstract
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Objectives : Recently, numerous studies reported that excessive generation of advanced glycation end products (AGEs) stimulated expression of skin wrinkle related proteins. This study aimed to evaluate inhibits skin wrinkle formation effect of Mori Folium (MF) through decreased AGEs.
Methods : To evaluate the skin wrinkle inhibition effect of MF, SD-rats were divided into three groups; normal rats (Nor), AGEs-induced rats (Con), AGEs-induce rats treated with MF at dose of 100㎎/㎏ body weight (MF). To induced AGEs, streptozotocin (50㎎/㎏) was injected intraperitoneally, and after 3 days, 100mM methyl glyoxal was administered orally for 3 weeks. After the experiment, the animal`s dorsal skin tissues and serum were separated and tested.
Results : The oral administration of MF suppressed the AGEs level in serum. Also, the AGEs in skin tissues was significantly reduced through treatment of MF compared with control group. Moreover, the expressions of AGEs related proteins such as polyclonal anti-N e-(carboxymethyl) lysine (CML), anti-N e-(carboxyethyl)lysine (CEL), AGE receptors (RAGE) were reduced in MF group compared with the control group in kidney and skin tissues. The matrix metallo proteinase-1 (MMP-1) reduced by MF treatment with the result that collagen type 1 alpha 2 (COL1A2) was improved that reduced by accumulation of AGEs.
Conclusion : The evidence of this study indicate that oral administration of MF reduces the levels of AGEs in serum, skin, and kidney tissues. In conclusion, MF inhibit skin wrinkle formation, suggesting the potential of anti-wrinkle material.
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KEYWORD
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Mori Folium, wrinkle formation, collagen, Advanced glycation end product
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